We culture T. brucei and P. falciparum within the lab, and collaborate closely with the Li group for bacterial studies. MIPS provides access to extensive advanced instrumentation for cell biology, molecular biology, biochemistry and analytical chemistry.
Infectious diseases cause extensive morbidity and mortality, and emergence of drug resistance threatens to render many common bacterial and parasitic infections untreatable.
Current projects in the Creek lab focus on Trypanosoma brucei (Human African Trypanosomiasis - HAT), Plasmodium falciparum (Malaria) and
Gram negative superbugs (Acinetobacter baumannii and Klebsiella
By improving our understanding of
metabolic networks and mechanisms of drug action we hope to facilitate the discovery and development of new medicines for infectious diseases.
Our key technology is metabolomics. The lab has recently installed a Q-Exactive LCMS platform and we also have nano-LC-Q-Exactive and UHPLC-QQQ platforms to allow analysis of a range of molecule types including drugs, metabolites, lipids and proteins.
Dr Creek's Bio
Darren completed his PhD in pharmaceutics at Monash University with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, leading to the discovery of OZ439, a potent and long-acting antimalarial currently in clinical trials. Darren then obtained first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda, which described the pharmacokinetics and tolerability of piperaquine in young children and revealed the systematic under-dosing of this population. Dr Creek has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow, and the Department of Biochemistry and Molecular Biology at the University of Melbourne.
During his CJ Martin fellowship, Darren developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.
Darren is currently a NHMRC Career Development Fellow and lecturer at the Monash Institute of Pharmaceutical Sciences and his group continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. His work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.
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