Google Scholar Profile:  Darren J Creek

Reviews/Book Chapters/Editorials:

        Giannangelo C, Ellis KM, Sexton AE, Stoessel D, Creek DJ. The role of metabolomics in antiparasitic drug discovery. Analysis of parasite biology – from metabolism to drug discovery. Muller S, Cerdan R, Guca E, Radulescu O, Eds. Wiley, 2016. Chapter 14. p321 (PDF)   

        Srivastava AS, Kowalski GM, Callahan DL, Meikle PJ, Creek DJ. Strategies for extending metabolomics studies with stable isotope labelling and fluxomics. Metabolites 2016; 6(4): 32

        Kim DH and Creek DJ. What role can metabolomics play in the discovery and development of new medicines for infectious diseases? Bioanalysis 2015; 7(6): 629-631  (Download PDF)

        Fiehn O, Putri SP, Saito K, Salek RM, Creek DJ. Metabolomics continues to expand: highlights from the 2015 metabolomics conference. Metabolomics. 2015; 11(5): 1036-1040

        Creek DJ, Dunn WB, Fiehn O, Griffin JL, Hall RD, Lei Z, Mistrik R, Neumann S, Schymanski EL, Sumner LW. Metabolite identification: are you sure? And how do your peers gauge your confidence? Metabolomics. 2014; 10 (3): 350-353 (Download PDF)

        Chokkathukalam A, Kim D-H, Barrett MP, Breitling R, Creek DJ. Stable isotope labeling studies in metabolomics: New insights into structure and dynamics of metabolic networks. Bioanalysis. 2014; 6 (4): 511-524  (Download PDF)

        Creek DJ and Barrett, MP. Determination of anti-protozoal drug mechanisms by metabolomics approaches. Parasitology. 2014; 141: 83-92 (Download PDF)

        Viant MR, Bearden DW, Creek DJ, Fiehn O and Robertson DG. Supporting the industry sector of the metabolomics community: the remit of the Metabolomics Society’s Industry Engagement Task Group. Metabolomics. 2014; 10 (4): 541-542

        Klonis N, Creek DJ and Tilley L. Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisininsCurrent Opinion in Microbiology. 2013; 16 (6), 722-727 (Download PDF)

        Creek DJ. Stable isotope labeled metabolomics improves identification of novel metabolites and pathways. Bioanalysis 2013; 5 (15), 1807-1810 

        Dunn WB, Erban A, Weber RJM, Creek DJ, Brown M, Breitling R, Hankemeier T, Goodacre R, Neumann S, Kopka J and Viant MR. Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. Metabolomics 2013; 9 (1): 44-66  (Download PDF)

        Creek DJ, Anderson J, McConville MJ and Barrett MP. Metabolomic analysis of trypanosomatid protozoaMolecular and Biochemical Parasitology 2012; 181 (2): 73-84 (Download PDF)

        Creek DJ. Metabolomics Databases. Dictionary of Bioinformatics and Computational Biology. 2014. M22

        Creek DJ, Vincent IM and Barrett MP. Pharmacological metabolomics in trypanosomes. Drug Discovery for Trypanosomatid Diseases. Jaeger T.; Koch O.; Flohe L., Eds. Wiley-VCH, 2013. 37-56 (Download PDF)

Original Articles

        Giannangelo C, Stingelin L, Yang T, Tilley LCharman SA, Creek DJ. Parasite-mediated degradation of synthetic ozonide antimalarials impacts in vitro antimalarial activity Antimicrobial Agents and Chemotherapy. 2018. 62(3): e01566-17 (PDF)

        Chou ES, Abidi SZ, Teye M, Leliwa-Sytek A, Rask TS, Cobbold SA, Tonkin-Hill GQ, Subramaniam KS, Sexton AE, Creek DJ, Daily JP, Duffy MF and Day KP. A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages. The FEBS Journal, 2018 doi:10.1111/febs.14370 (Accepted 12/12/2017)

        Wang M, Siddiqui G, Gustafsson OJR, Käkinen A, Javed I, Voelcker NH, Creek DJ, Ke PC, Davis TP. Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles. Small. 2017. 13(36): 1701528.

        Mwenechanya R, Kovářová J, Dickens NJ, Manikhandan M, Herzyk P, Vincent IM, Weidt SK, Burgess KE, Burchmore RJS, Pountain AW, Smith TK, Creek DJ, Kim D-H, Lepesheva GI, Barrett MP. Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicanaPLoS Neglected
Tropical Diseases. 2017. 11(6): e0005649

        Siddiqui G, Srivastava A, Russell AS, Creek DJ. Multi-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin resistant Plasmodium falciparum Journal of Infectious Diseases. 2017. 215(9): 1435-1444 (PDF)

        Counihan NA, Chisholm SA, Bullen HE, Srivastava A, Sanders PR, Jonsdottir TK, Weiss GE, Ghosh S, Crabb BS, Creek DJ, Gilson PR, de Koning-Ward TF. Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate. eLife. 2017. 6: e23217 

        Srivastava, A*, Evans, KJ*, Sexton, AE, Schofield, L, Creek, DJMetabolomics-based elucidation of active metabolic pathways in erythrocytes and HSC-derived reticulocytesJournal of Proteome Research. 16(4): 1492-1505

        Maifiah MHM, Creek DJ*, Nation RL, Forrest A, Tsuji BT, Velkov T, Li J*. Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumanniiScientific Reports. 2017. 7: 45527

        Murray GL, Tsyganov K, Kostoulias XP, Bulach DM, Creek DJ, Powell D, Boyce JD, Paulsen IT, Peleg AY. Global gene expression profile of Acinetobacter baumannii during bacteremiaJournal of Infectious Diseases. 2017. 215(s1): s52-s57

        Alzahrani KJH, Ali JAM, Eze AA, Limm LW, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP. Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: implications for pyrimidine-based chemotherapyInternational Journal for Parasitology: Drugs and Drug Resistance2017. 7(2): 206-226

        Creek DJ, Chua HH, Cobbold SA, Nijagal B, Macrae JI, Dickerman BK, Gilson PR, Ralph SA, McConville MJ. Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action. Antimicrobial Agents and Chemotherapy. 2016. 60(11): 6650-6663 (PDF)

        Bhuiyan MS, Ellett F, Murray GL, Kostoulias X, Cerqueira G, Schulze K, Maifiah H, Li J, Creek DJ, Lieschke GJ, Peleg AY. Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis. Proceedings of the National Academy of Sciences. 2016. 113(34): 9599-9604

        Stoessel D, Nowell CJ, Jones AJ, Ferrins L, Ellis KM, Riley J, Rahmani R, Read KD, McConville MJ, Avery VM, Baell JB*, Creek DJ*. Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide. Metabolomics. 2016. 12(7): 1-14 (View)

        Peterson AL, Walker AK, Sloan EK, Creek DJ. Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells. Metabolites. 2016. 6(4): 30

         Maifiah MHM, Cheah S-E, Johnson MD, Han M, Boyce JD, Thamlikitkul V, Forrest A, Kaye KS, Hertzog P, Purcell AW, Song J, Velkov T, Creek DJ*, Li J* (*Corresponding authors) Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii. Scientific Reports2016. 6:22287

        Srivastava A, Philip N, Hughes KR, Georgiou K, MacRae JI, Barrett MP, Creek DJ, McConville MJ, Waters AP. Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens201612(12): e1006094

        Neubauer HA, Pham DH, Zebol JR, Moretti PA, Peterson AL, Leclercq TM, Chan H, Powell JA, Pitman MR, Samuel MS, Bonder CS, Creek DJ, Gliddon BL, Pitson SM. An oncogenic role for sphingosine kinase 2. Oncotarget. 2016. 7(40): 64886-64899

        Tchaparian E, Sambol NC, Arinaitwe E, McCormack SA, Bigira V, Wanzira H, Muhindo M, Creek DJ, Sukumar N, Blessborn D, Tappero JW, Kakuru A, Bergqvist Y, Aweeka FT, Parikh S. Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malariaJournal of Infectious Diseases. 2016. 214(8): 1243-1251

Yang T,  Xie S, Cao P, Giannangelo C, McCaw J, Creek DJ, Charman SA, Klonis N, Tilley L. A comparison of the exposure time-dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wildtype and mutant Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 2016. 60(8): 4501-4510

Aurelio L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek DJ, Pitson SM, Flynn BL. From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-chlorophenyl) thiazol-2-ylamino) phenol (SKI-II). Journal of Medicinal Chemistry. 2016. 59(3): 965-984 

Tran TB, Cheah S-E, Heidi HY, Bergen PJ, Nation RL, Creek DJ, Purcell A, Forrest A, Doi Y, Song J, Velkov T, Li J. Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii. The Journal of Antibiotics2016. 69(6): 415-21

        Creek DJ, Mazet M, Achcar F, Anderson J, Kim DH, Kamour R, Morand P, Millerioux Y, Biran M, Kerkhoven EJ, Chokkathukalam A, Burgess KEV, Breitling R, Watson DG, Bringaud F and Barrett MP. Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens. 2015. 11(3): e1004689

        Srivastava, A, Creek DJ, Evans KJ, De Souza D, Schofield L, Müller S, Barrett MP, McConville MJ, Waters AP. Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria ParasitesPLoS Pathogens. 2015. 11(6): e1004882

        Trochine A, Creek DJ, Faral-Tello P, Barrett MP and Robello C. Bestatin induces specific changes in Trypanosoma cruzi dipeptide poolAntimicrobial Agents and Chemotherapy. 2015. 59(5): 2921-2925

        Kozicki M, Creek DJ, Sexton A, Morahan BJ, Wesełucha-Birczyńska A and Wood BR.An Attenuated Total Reflection (ATR) and Raman spectroscopic investigation into the effects of chloroquine on Plasmodium falciparum-infected red blood cells. Analyst. 2015140(7):2236-46

        Sambol N, Yan L, Creek DJ, McCormack S, Arinaitwe E, Bigira V, Wanzira H, Kakuru A, Tappero JW, Tarning J, Lindegardh N, Nosten F, Aweeka FT and Parikh S. Population pharmacokinetics of piperaquine in young Ugandan children treated with dihydroartemisinin-piperaquine for uncomplicated malariaClinical Pharmacology & Therapeutics. 2015. 98(1): 87-95

        Cobbold SA, Chua HH, Nijagal B, Creek DJ, Ralph SA, McConville MJ. Metabolic dysregulation induced in Plasmodium falciparum by dihydroartemisinin and other front line antimalarial drugs. Journal of Infectious Diseases. 2016. 213 (2): 276-86

        Creek DJ*, Alkhaldi, AAM*, Ibrahim, H, Kim, DH, Quashie, NB, Burgess, KE, Changtam, C, Barrett, MP, Suksamrarn, A and Koning HP. PotentTrypanocidal Curcumin Analogs Bearing a Mono-enone Linker Motif Act onTrypanosoma Brucei by Forming an Adduct with Trypanothione. Molecular Pharmacology. 201487 (3): 451-64

        Oppenheim RD, Creek DJ, Macrae JI, Modrzynska KK, Pino P, et al. BCKDH: The Missing Link inApicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathogens 2014; 10(7): e1004263.

        Trochine A, Creek DJ, Faral-Tello P, Barrett MP and Robello C. Benznidazole Biotransformation and MultipleTargets in Trypanosoma cruzi Revealedby Metabolomics. PLoS Neglected Tropical Diseases. 2014. 8 (5), e2844

        Shameer S, Logan-Klumpler FJ, Vinson F, et al., TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research. 2014. 43 (Database issue): D637-44

        Creek DJ, Nijagal B, Kim D-H, Rojas F, Matthews KR, Barrett MP. Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrobial Agents and Chemotherapy. 2013. 57 (6): 2768-2779

       Creek DJ, Bigira V, McCormack S, Arinaitwe E, Wanzira H, Kakuru A, Tappero JW, Sandison TG, Lindegardh N, Nosten F, Aweeka FT and Parikh S. Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants. Journal of Infectious Diseases. 2013. 207(11): 1646-1654 

Ali JAM, Creek DJ, Burgess K, Allison HC, Field MC, Maser P and De Koning HP. Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Molecular Pharmacology. 2013. 83 (2): 439-453

Limenitakis J, Oppenheim RD, Creek DJ, Foth BJ, Barrett MP and Soldati-Favre D. The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii. Molecular Microbiology. 2013. 87 (4): 894–908

Chokkathukalam A, Jankevics A, Creek DJ, Achcar F, Barrett MP and Breitling R. mzMatch–ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics. 2013. 29 (2): 281-283 

Creek DJ, Chokkathukalam A, Jankevics A, Burgess KEV, Breitling R and Barrett MP. Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry. 2012. 84 (20): 8442–8447 

Creek DJ, Jankevics A, Burgess KEV, Breitling R and Barrett MP. IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data. Bioinformatics. 2012. 28 (7): 1048-9  (

Vincent IM, Creek DJ, Burgess K, Woods DJ, Burchmore RJS and Barrett MP. Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei. PLoS Neglected Tropical Diseases. 2012. 6 (5): e1618. 

Zhang T, Creek DJ, Barrett MP, Blackburn G and Watson DG. Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry. 2012. 84 (4): 1994-2001

Creek DJ, Jankevics, A, Breitling, R, Watson, DG, Barrett, MP and Burgess, KEV. Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry. 2011. 83 (22): 8703-10

Burgess K, Creek D, Dewsbury P, Cook K and Barrett MP. Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry. 2011. 25 (22): 3447-52 (Download PDF)

Leader DP, Burgess K, Creek D and Barrett MP. Pathos: A web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry. 2011. 25 (22): 3422-6 

Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FCK, Chollet J, Craft JC, Creek DJ, Dong Y, Matile, H, Maurer, M, Morizzi, J, Nguyen, T, Papastogiannidis, P, Scheurer, C, Shackleford, DM, Sriraghavan, K, Stingelin, L, Tang, Y, Urwyler, H, Wang, X, White, KL, Wittlin, S, Zhou, L and Vennerstrom, JL. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences. 2011. 108 (11): 4400-5

Creek DJ, Bigira V, Arinaitwe E, Wanzira H, Kakuru A, Tappero JW, Kamya MR, Dorsey G, Sandison TG. Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared to artemether-lumefantrine for uncomplicated malaria. American Journal of Tropical Medicine & Hygiene. 2010. 83(4): 873-875 (Download PDF)

Vincent IM, Creek D, Watson DG, Kamleh MA, Woods DJ, Wong PE, Burchmore RJS and Barrett MP. A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens. 2010. 6 (11): e1001204

Creek DJ, Ryan E, Charman WN, Chiu FCK, Prankerd RJ, Vennerstrom JL, Charman SA. Stability of peroxide antimalarials in the presence of human hemoglobin. Antimicrobial Agents and Chemotherapy. 2009 53(8): 3496-3500.

Wang X, Creek DJ, Schiaffo CE, Dong Y, Chollet J, Scheurer C, Wittlin S, Charman SA, Dussault PH,  Wood JK, Vennerstrom JL. Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorganic & Medicinal Chemistry Letters. 2009. 19(16): 4542-4545 

Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R and Vennerstrom JL. The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry. 2009. 53(1): 481-491

Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, Dong Y, Vennerstrom JL, Charman SA. Relationship between antimalarial activity and haem alkylation for dispiro-1,2,4-trioxolane antimalarials. Antimicrobial Agents and Chemotherapy. 2008. 52(4): 1290-1296 

Creek DJ, Chalmers DK, Charman WN, Duke BJ. Quantum chemical study of the intermediate complex required for iron-mediated reactivity and antimalarial activity of dispiro-1,2,4-trioxolanes. Journal of Molecular Graphics and Modelling. 2008. 27(3): 394-400

Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, McCullough KJ, Dong Y, Vennerstrom JL, Charman SA. Iron-mediated degradation kinetics of substituted 1,2,4-trioxolane antimalarials. Journal of Pharmaceutical Sciences. 2007. 96(11): 2945-2956

Dong Y, Creek DJ, Chollet J, Matile H, Charman SA, Wittlin S, Wood JK, Vennerstrom JL. Comparative antimalarial activity of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). Antimicrobial Agents and Chemotherapy. 2007. 51(8): 3033-3035 

Wang X, Dong Y, Wittlin S, Creek DJ, Chollet J, Charman SA, Vennerstrom JL. Spiro and dispiro-1,2-dioxolanes: Contribution of iron(II)-mediated one-electron vs. two-electron reduction to the activity of antimalarial peroxides. Journal of Medicinal Chemistry. 2007. 50(23): 5840-584 

Padmanilayam M, Scorneaux B, Dong Y, Chollet J, Matile H, Charman SA, Creek DJ, Charman WN, Santo Tomas J, Scheurer C, Wittlin S, Brun R, Vennerstrom JL. Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine. Bioorganic & Medicinal Chemistry Letters. 2006. 16(21): 5542-5545

        Creek DJ, Chiu FCK, Prankerd RJ, Charman SA, Charman WN. Kinetics of iron-mediated artemisinin degradation: Effect of solvent composition and iron salt. Journal of Pharmaceutical Sciences. 2005. 94(8): 1820-1829

J.L. Vennerstrom, Y. Dong, S.A. Charman, S. Wittlin, J. Chollet, D.J. Creek, X. Wang, K. Sriraghavan, L. Zhou, H. Matile, W.N. Charman. Dispiro 1,2,4-trioxolane antimalarials. Medicines for Malaria Venture. US Patent # 8,067,620, 2011 ; 31 October 2007  

Darren Creek,
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Darren Creek,
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Darren Creek,
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Darren Creek,
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Darren Creek,
20 Apr 2016, 19:44
Darren Creek,
15 Feb 2017, 15:12
Darren Creek,
20 Apr 2016, 19:42
Darren Creek,
20 Apr 2016, 19:42
Darren Creek,
7 Mar 2018, 14:28
Darren Creek,
20 Apr 2016, 19:18
Darren Creek,
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Darren Creek,
9 Apr 2017, 17:35