Google Scholar Profile:
Darren J Creek Reviews/Book Chapters/Editorials: Bell JS, Bell JA, Creek DJ. Off-label prescribing in the midst of a pandemic: The case of hydroxychloroquine. Aust J Gen Pract. 2020 April A Srivastava, DJ Creek Using the IDEOM Workflow for LCMS-Based Metabolomics Studies of Drug MechanismsComputational Methods and Data Analysis for Metabolomics, 2020, pp 419-4452020. Ashton TD, Devine SM, Möhrle JJ, Laleu B, Burrows JN,
Charman SA, Creek DJ, Sleebs BE. The Development Process for Discovery
and Clinical Advancement of Modern Antimalarials. J Med Chem. 2019 Dec
12;62(23):10526-10562. Sexton AE, Doerig C, Creek DJ, Carvalho TG. Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions. ACS Infect Dis. 2019 Aug 9;5(8):1269-1278. Giannangelo C, Fowkes FJI, Simpson JA, Charman SA, Creek DJ. Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria. Trends Parasitol. 2019 Jul;35(7):529-543. A. Srivastava, DJ Creek. Discovery and validation of clinical biomarkers of cancer: a review combining metabolomics and proteomics. Proteomics, 2019, 19, 1700448. https://doi.org/10.1002/pmic.201700448 Giannangelo C, Ellis KM, Sexton AE, Stoessel D, Creek DJ. The role of metabolomics in antiparasitic drug discovery. Analysis of parasite biology – from metabolism to drug discovery. Muller S, Cerdan R, Guca E, Radulescu O, Eds. Wiley, 2016. Chapter 14. p321 (PDF) Srivastava AS, Kowalski GM, Callahan DL, Meikle PJ, Creek DJ. Strategies for extending metabolomics studies with stable isotope labelling and fluxomics. Metabolites 2016; 6(4): 32 Kim DH and Creek DJ. What role can metabolomics play in the discovery and development of new medicines for infectious diseases? Bioanalysis 2015; 7(6): 629-631 (Download PDF) Fiehn O, Putri SP, Saito K, Salek RM, Creek DJ. Metabolomics continues to expand: highlights from the 2015 metabolomics conference. Metabolomics. 2015; 11(5): 1036-1040 Creek DJ, Dunn WB, Fiehn O, Griffin JL, Hall RD, Lei Z, Mistrik R, Neumann S, Schymanski EL, Sumner LW. Metabolite identification: are you sure? And how do your peers gauge your confidence? Metabolomics. 2014; 10 (3): 350-353 (Download PDF) Chokkathukalam A, Kim D-H, Barrett MP, Breitling R, Creek DJ. Stable isotope labeling studies in metabolomics: New insights into structure and dynamics of metabolic networks. Bioanalysis. 2014; 6 (4): 511-524 (Download PDF) Creek DJ and Barrett, MP. Determination of anti-protozoal drug mechanisms by metabolomics approaches. Parasitology. 2014; 141: 83-92 (Download PDF) Viant MR, Bearden DW, Creek DJ, Fiehn O and Robertson DG. Supporting the industry sector of the metabolomics community: the remit of the Metabolomics Society’s Industry Engagement Task Group. Metabolomics. 2014; 10 (4): 541-542 Klonis N, Creek DJ and Tilley L. Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins. Current Opinion in Microbiology. 2013; 16 (6), 722-727 (Download PDF) Creek DJ. Stable isotope labeled metabolomics improves identification of novel metabolites and pathways. Bioanalysis 2013; 5 (15), 1807-1810 Dunn WB, Erban A, Weber RJM, Creek DJ, Brown M, Breitling R, Hankemeier T, Goodacre R, Neumann S, Kopka J and Viant MR. Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. Metabolomics 2013; 9 (1): 44-66 (Download PDF) Creek DJ, Anderson J, McConville MJ and Barrett MP. Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology 2012; 181 (2): 73-84 (Download PDF) Creek DJ. Metabolomics Databases. Dictionary of Bioinformatics and Computational Biology. 2014. M22 Creek DJ, Vincent IM and Barrett MP. Pharmacological metabolomics in trypanosomes. Drug Discovery for Trypanosomatid Diseases. Jaeger T.; Koch O.; Flohe L., Eds. Wiley-VCH, 2013. 37-56 (Download PDF) Original Articles Qiao, R., Fu, C., Li, Y., Qi, X., Ni, D., Nandakumar, A., Siddiqui, G., Wang, H., Zhang, Z., Wu, T., Zhong, J., Tang, S.‐Y., Pan, S., Zhang, C., Whittaker, M.R., Engle, J.W., Creek, D.J., Caruso, F., Ke, P.C., Cai, W., Whittaker, A.K. and Davis, T.P. (2020), Sulfoxide‐Containing Polymer‐Coated Nanoparticles Demonstrate Minimal Protein Fouling and Improved Blood Circulation. Adv. Sci. doi:10.1002/advs.202000406. Giannangelo C, Siddiqui G, De Paoli A, Anderson BM, Edgington-Mitchell LE, Charman SA, Creek DJ. System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion. bioRxiv 2020.03.23.003376;doi: https://doi.org/10.1101/2020.03.23.003376 Langston-Cox
A, Anderson D, Creek
DJ, Palmer K, Wallace EM,
Marshall SA. Measuring Sulforaphane and Its
Metabolites in Human Plasma: A High Throughput Method. Molecules. 2020 Feb 13;25(4):829. doi:
10.3390/molecules25040829. Birrell GW, Challis MP, De Paoli A, Anderson D, Devine SM, Heffernan GD, Jacobus DP, Edstein MD, Siddiqui G, Creek DJ. Multi-omic characterisation of the mode of action of a potent new antimalarial compound, JPC-3210, against Plasmodium falciparum.Mol Cell Proteomics. 2019 Dec 13.pii: mcp.RA119.001797. Giannangelo C, Anderson D, Wang X, Vennerstrom JL, Charman SA, Creek DJ. Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum. ACS Infect Dis. 2019 Dec 13;5(12):2076-2086. Hussein M, Han ML, Zhu Y, Zhou QT, Lin YW, Hancock REW, Hoyer D, Creek DJ, Li J, Velkov T. Metabolomics study of the synergistic killing of polymyxin B in combination with amikacin against polymyxin-susceptible and -resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019 Oct 14. pii: AAC.01587-19. Han ML, Liu X, Velkov T, Lin YW, Zhu Y, Creek DJ, Barlow CK, Yu HH, Zhou Z, Zhang J, Li J. Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii. Front Pharmacol. 2019 Jul 4;10:754. Mahamad Maifiah MH, Velkov T, Creek DJ, Li J. Global Metabolic Analyses of Acinetobacter baumannii. Methods Mol Biol. 2019;1946:321-328. Han ML, Zhu Y, Creek DJ, Lin YW, Gutu AD, Hertzog P, Purcell T, Shen HH, Moskowitz SM, Velkov T, Li J. Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa. mSystems. 2019 Jan 8;4(1). pii: e00149-18. Hussein M, Han ML, Zhu Y, Schneider-Futschik EK, Hu X, Zhou QT, Lin YW, Anderson D, Creek DJ, Hoyer D, Li J, Velkov T. Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa. Comput Struct Biotechnol J. 2018 Nov 10;16:587-599. Han ML, Liu X, Velkov T, Lin YW, Zhu Y, Li M, Yu HH, Zhou Z, Creek DJ, Zhang J, Li J. Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii. Front Microbiol. 2018 Nov 16;9:2776. Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP. Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Negl Trop Dis. 2018 May 14;12(5):e0006450. Tran TB, Bergen PJ, Creek DJ, Velkov T, Li J. Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study. Front Pharmacol. 2018 Apr 16;9:359. Wang M, Gustafsson OJR, Siddiqui G, Javed I, Kelly HG, Blin T, Yin H, Kent SJ, Creek DJ, Kempe K, Ke PC, Davis TP. Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline). Nanoscale. 2018 Jun 14;10(23):10863-10875. Han ML, Zhu Y, Creek DJ, Lin YW, Anderson D, Shen HH, Tsuji B, Gutu AD, Moskowitz SM, Velkov T, Li J. Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02656-17. Tjhin ET, Spry C, Sewell AL, Hoegl A, Barnard L, Sexton AE, Siddiqui G, Howieson VM, Maier AG, Creek DJ, Strauss E, Marquez R, Auclair K, Saliba KJ. Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues. PLoS Pathog. 2018 Apr 3;14(4):e1006918. De Livera AM, Olshansky G, Simpson JA, Creek DJ. NormalizeMets: assessing, selecting and implementing statistical methods for normalizing metabolomics data. Metabolomics. 2018. 14-54 (PDF) Giannangelo C,
Stingelin L,
Yang T, Tilley L, Charman SA, Creek DJ. Parasite-mediated
degradation of synthetic ozonide
antimalarials
impacts in vitro antimalarial activity
Antimicrobial
Agents and Chemotherapy. 2018. 62(3): e01566-17 (PDF) Chou ES, Abidi SZ, Teye M, Leliwa-Sytek A, Rask TS, Cobbold SA, Tonkin-Hill GQ, Subramaniam KS, Sexton AE, Creek DJ, Daily JP, Duffy MF and Day KP. A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages. The FEBS Journal, 2018 doi:10.1111/febs.14370 (Accepted 12/12/2017) Siddiqui G, Srivastava A, Russell AS, Creek DJ. Multi-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin resistant Plasmodium falciparum Journal of Infectious Diseases. 2017. 215(9): 1435-1444 (PDF) Counihan NA, Chisholm SA, Bullen HE, Srivastava A, Sanders PR, Jonsdottir TK, Weiss GE, Ghosh S, Crabb BS, Creek DJ, Gilson PR, de Koning-Ward TF. Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate. eLife. 2017. 6: e23217 Srivastava, A*, Evans, KJ*, Sexton, AE, Schofield, L, Creek, DJ. Metabolomics-based elucidation of active metabolic pathways in erythrocytes and HSC-derived reticulocytes. Journal of Proteome Research. 16(4): 1492-1505 Maifiah MHM, Creek DJ*, Nation RL, Forrest A, Tsuji BT, Velkov T, Li J*. Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii. Scientific Reports. 2017. 7: 45527 Murray GL, Tsyganov K, Kostoulias XP, Bulach DM, Creek DJ, Powell D, Boyce JD, Paulsen IT, Peleg AY. Global gene expression profile of Acinetobacter baumannii during bacteremia. Journal of Infectious Diseases. 2017. 215(s1): s52-s57 Alzahrani KJH, Ali JAM, Eze AA, Limm LW, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP. Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: implications for pyrimidine-based chemotherapy. International Journal for Parasitology: Drugs and Drug Resistance. 2017. 7(2): 206-226 Creek DJ, Chua HH, Cobbold SA, Nijagal B, Macrae JI, Dickerman BK, Gilson PR, Ralph SA, McConville MJ. Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action. Antimicrobial Agents and Chemotherapy. 2016. 60(11): 6650-6663 (PDF) Bhuiyan MS, Ellett F, Murray GL, Kostoulias X, Cerqueira G, Schulze K, Maifiah H, Li J, Creek DJ, Lieschke GJ, Peleg AY. Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis. Proceedings of the National Academy of Sciences. 2016. 113(34): 9599-9604 Stoessel
D, Nowell CJ, Jones AJ, Ferrins L, Ellis KM, Riley J, Rahmani R, Read KD,
McConville MJ, Avery VM, Baell JB*, Creek DJ*. Metabolomics and
lipidomics reveal perturbation of sphingolipid metabolism by a novel
anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide. Metabolomics.
2016. 12(7): 1-14 (View) Peterson AL, Walker AK, Sloan EK, Creek DJ. Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells. Metabolites. 2016. 6(4): 30 Maifiah
MHM, Cheah S-E, Johnson MD, Han M, Boyce JD, Thamlikitkul V, Forrest A, Kaye
KS, Hertzog P, Purcell AW, Song J, Velkov T, Creek DJ*, Li J*
(*Corresponding authors) Global metabolic analyses identify key differences
in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter
baumannii. Scientific Reports. 2016. 6:22287 Srivastava A, Philip N, Hughes KR, Georgiou K, MacRae JI, Barrett MP, Creek DJ, McConville MJ, Waters AP. Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens. 2016. 12(12): e1006094 Neubauer HA, Pham DH, Zebol JR, Moretti PA, Peterson AL, Leclercq TM, Chan H, Powell JA, Pitman MR, Samuel MS, Bonder CS, Creek DJ, Gliddon BL, Pitson SM. An oncogenic role for sphingosine kinase 2. Oncotarget. 2016. 7(40): 64886-64899 Tchaparian E, Sambol NC, Arinaitwe E, McCormack SA, Bigira V, Wanzira H, Muhindo M, Creek DJ, Sukumar N, Blessborn D, Tappero JW, Kakuru A, Bergqvist Y, Aweeka FT, Parikh S. Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria. Journal of Infectious Diseases. 2016. 214(8): 1243-1251 Yang
T, Xie S, Cao P, Giannangelo C, McCaw J,
Creek DJ, Charman SA, Klonis N, Tilley L. A comparison of the exposure time-dependence of the activities of synthetic ozonide antimalarials
and dihydroartemisinin against K13 wildtype and mutant Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 2016. 60(8): 4501-4510 Aurelio
L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek
DJ, Pitson SM, Flynn BL. From Sphingosine Kinase to Dihydroceramide
Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme
Inhibitory and Anticancer Activity of 4-((4-(4-chlorophenyl) thiazol-2-ylamino)
phenol (SKI-II). Journal of Medicinal Chemistry. 2016. 59(3): 965-984 Tran TB,
Cheah S-E, Heidi HY, Bergen PJ, Nation RL, Creek DJ, Purcell A, Forrest
A, Doi Y, Song J, Velkov T, Li J. Anthelmintic closantel enhances bacterial
killing of polymyxin B against multidrug-resistant Acinetobacter baumannii.
The Journal of Antibiotics. 2016. 69(6): 415-21 Creek DJ, Mazet M, Achcar F, Anderson J, Kim DH, Kamour R, Morand P, Millerioux Y, Biran M, Kerkhoven EJ, Chokkathukalam A, Burgess KEV, Breitling R, Watson DG, Bringaud F and Barrett MP. Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens. 2015. 11(3): e1004689 Srivastava, A, Creek DJ, Evans KJ, De Souza D, Schofield L, Müller S, Barrett MP, McConville MJ, Waters AP. Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites. PLoS Pathogens. 2015. 11(6): e1004882 Trochine A, Creek DJ, Faral-Tello P, Barrett MP and Robello C. Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool. Antimicrobial Agents and Chemotherapy. 2015. 59(5): 2921-2925 Kozicki M, Creek DJ, Sexton A, Morahan BJ, Wesełucha-Birczyńska A and Wood BR.An Attenuated Total Reflection (ATR) and Raman spectroscopic investigation into the effects of chloroquine on Plasmodium falciparum-infected red blood cells. Analyst. 2015. 140(7):2236-46 Sambol N, Yan L, Creek DJ, McCormack S, Arinaitwe E, Bigira V, Wanzira H, Kakuru A, Tappero JW, Tarning J, Lindegardh N, Nosten F, Aweeka FT and Parikh S. Population pharmacokinetics of piperaquine in young Ugandan children treated with dihydroartemisinin-piperaquine for uncomplicated malaria. Clinical Pharmacology & Therapeutics. 2015. 98(1): 87-95 Cobbold SA, Chua HH, Nijagal B, Creek DJ, Ralph SA, McConville MJ. Metabolic dysregulation induced in Plasmodium falciparum by dihydroartemisinin and other front line antimalarial drugs. Journal of Infectious Diseases. 2016. 213 (2): 276-86 Creek DJ*, Alkhaldi, AAM*, Ibrahim, H, Kim, DH, Quashie, NB, Burgess, KE, Changtam, C, Barrett, MP, Suksamrarn, A and Koning HP. PotentTrypanocidal Curcumin Analogs Bearing a Mono-enone Linker Motif Act onTrypanosoma Brucei by Forming an Adduct with Trypanothione. Molecular Pharmacology. 2014. 87 (3): 451-64 Oppenheim RD, Creek DJ, Macrae JI, Modrzynska KK, Pino P, et al. BCKDH: The Missing Link inApicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathogens 2014; 10(7): e1004263. Trochine A, Creek DJ, Faral-Tello P, Barrett MP and Robello C. Benznidazole Biotransformation and MultipleTargets in Trypanosoma cruzi Revealedby Metabolomics. PLoS Neglected Tropical Diseases. 2014. 8 (5), e2844 Shameer S, Logan-Klumpler FJ, Vinson F, et al., TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research. 2014. 43 (Database issue): D637-44 Creek DJ, Nijagal B, Kim D-H, Rojas F, Matthews KR, Barrett MP. Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrobial Agents and Chemotherapy. 2013. 57 (6): 2768-2779 Creek DJ, Bigira V, McCormack S, Arinaitwe E, Wanzira H, Kakuru A, Tappero JW, Sandison TG, Lindegardh N, Nosten F, Aweeka FT and Parikh S. Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants. Journal of Infectious Diseases. 2013. 207(11): 1646-1654 Ali JAM, Creek DJ, Burgess K, Allison HC, Field MC, Maser P and De Koning HP. Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Molecular Pharmacology. 2013. 83 (2): 439-453 Limenitakis J, Oppenheim RD, Creek DJ, Foth BJ, Barrett MP and Soldati-Favre D. The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii. Molecular Microbiology. 2013. 87 (4): 894–908 Chokkathukalam A, Jankevics A, Creek DJ, Achcar F, Barrett MP and Breitling R. mzMatch–ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics. 2013. 29 (2): 281-283 Creek DJ, Chokkathukalam A, Jankevics A, Burgess KEV, Breitling R and Barrett MP. Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry. 2012. 84 (20): 8442–8447 Creek DJ, Jankevics A, Burgess KEV, Breitling R and Barrett MP. IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data. Bioinformatics. 2012. 28 (7): 1048-9 (http://mzmatch.sourceforge.net/ideom.php) Vincent IM, Creek DJ, Burgess K, Woods DJ, Burchmore RJS and Barrett MP. Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei. PLoS Neglected Tropical Diseases. 2012. 6 (5): e1618. Zhang T, Creek DJ, Barrett MP, Blackburn G and Watson DG. Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry. 2012. 84 (4): 1994-2001 Creek DJ, Jankevics, A, Breitling, R, Watson, DG, Barrett, MP and Burgess, KEV. Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry. 2011. 83 (22): 8703-10 Burgess K, Creek D, Dewsbury P, Cook K and Barrett MP. Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry. 2011. 25 (22): 3447-52 (Download PDF) Leader DP, Burgess K, Creek D and Barrett MP. Pathos: A web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry. 2011. 25 (22): 3422-6 Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FCK, Chollet J, Craft JC, Creek DJ, Dong Y, Matile, H, Maurer, M, Morizzi, J, Nguyen, T, Papastogiannidis, P, Scheurer, C, Shackleford, DM, Sriraghavan, K, Stingelin, L, Tang, Y, Urwyler, H, Wang, X, White, KL, Wittlin, S, Zhou, L and Vennerstrom, JL. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences. 2011. 108 (11): 4400-5 Creek DJ, Bigira V, Arinaitwe E, Wanzira H, Kakuru A, Tappero JW, Kamya MR, Dorsey G, Sandison TG. Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared to artemether-lumefantrine for uncomplicated malaria. American Journal of Tropical Medicine & Hygiene. 2010. 83(4): 873-875 (Download PDF) Vincent IM, Creek D, Watson DG, Kamleh MA, Woods DJ, Wong PE, Burchmore RJS and Barrett MP. A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens. 2010. 6 (11): e1001204 Creek DJ, Ryan E, Charman WN, Chiu FCK, Prankerd RJ, Vennerstrom JL, Charman SA. Stability of peroxide antimalarials in the presence of human hemoglobin. Antimicrobial Agents and Chemotherapy. 2009 53(8): 3496-3500. Wang X, Creek DJ, Schiaffo CE, Dong Y, Chollet J, Scheurer C, Wittlin S, Charman SA, Dussault PH, Wood JK, Vennerstrom JL. Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorganic & Medicinal Chemistry Letters. 2009. 19(16): 4542-4545 Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R and Vennerstrom JL. The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry. 2009. 53(1): 481-491 Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, Dong Y, Vennerstrom JL, Charman SA. Relationship between antimalarial activity and haem alkylation for dispiro-1,2,4-trioxolane antimalarials. Antimicrobial Agents and Chemotherapy. 2008. 52(4): 1290-1296 Creek DJ, Chalmers DK, Charman WN, Duke BJ. Quantum chemical study of the intermediate complex required for iron-mediated reactivity and antimalarial activity of dispiro-1,2,4-trioxolanes. Journal of Molecular Graphics and Modelling. 2008. 27(3): 394-400 Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, McCullough KJ, Dong Y, Vennerstrom JL, Charman SA. Iron-mediated degradation kinetics of substituted 1,2,4-trioxolane antimalarials. Journal of Pharmaceutical Sciences. 2007. 96(11): 2945-2956 Dong Y, Creek DJ, Chollet J, Matile H, Charman SA, Wittlin S, Wood JK, Vennerstrom JL. Comparative antimalarial activity of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). Antimicrobial Agents and Chemotherapy. 2007. 51(8): 3033-3035 Wang X, Dong Y, Wittlin S, Creek DJ, Chollet J, Charman SA, Vennerstrom JL. Spiro and dispiro-1,2-dioxolanes: Contribution of iron(II)-mediated one-electron vs. two-electron reduction to the activity of antimalarial peroxides. Journal of Medicinal Chemistry. 2007. 50(23): 5840-584 Padmanilayam M, Scorneaux B, Dong Y, Chollet J, Matile H, Charman SA, Creek DJ, Charman WN, Santo Tomas J, Scheurer C, Wittlin S, Brun R, Vennerstrom JL. Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine. Bioorganic & Medicinal Chemistry Letters. 2006. 16(21): 5542-5545 Creek DJ, Chiu FCK, Prankerd RJ, Charman SA, Charman WN. Kinetics of iron-mediated artemisinin degradation: Effect of solvent composition and iron salt. Journal of Pharmaceutical Sciences. 2005. 94(8): 1820-1829 Patents: J.L. Vennerstrom, Y. Dong, S.A. Charman, S. Wittlin, J. Chollet, D.J. Creek, X. Wang, K. Sriraghavan, L. Zhou, H. Matile, W.N. Charman. Dispiro 1,2,4-trioxolane antimalarials. Medicines for Malaria Venture. US Patent # 8,067,620, 2011 ; 31 October 2007 |
